KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PMS1
All Species:
17.88
Human Site:
Y280
Identified Species:
35.76
UniProt:
P54277
Number Species:
11
Phosphosite Substitution
Charge Score:
0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P54277
NP_000525.1
932
105830
Y280
L
K
L
I
R
H
H
Y
N
L
K
C
L
K
E
Chimpanzee
Pan troglodytes
XP_515987
1061
120272
Y409
L
K
L
I
R
H
H
Y
N
L
K
C
L
K
E
Rhesus Macaque
Macaca mulatta
XP_001103074
831
93641
Y235
H
C
E
E
S
Q
I
Y
L
S
G
F
L
P
K
Dog
Lupus familis
XP_536002
930
105612
Y280
L
K
L
I
R
H
Y
Y
N
L
K
C
L
K
E
Cat
Felis silvestris
Mouse
Mus musculus
P54279
859
95207
T259
C
E
E
Y
G
L
S
T
S
G
R
H
K
T
F
Rat
Rattus norvegicus
NP_001009535
919
103710
Y280
L
K
L
I
R
H
Y
Y
N
L
K
C
L
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507554
871
92244
D271
S
R
P
V
R
Q
R
D
I
L
K
V
I
R
Q
Chicken
Gallus gallus
NP_001006508
916
103017
Y276
Q
K
E
I
L
K
Y
Y
S
V
L
M
Q
K
D
Frog
Xenopus laevis
NP_001079545
925
103654
H280
M
K
M
V
R
L
Y
H
T
Q
S
L
N
K
G
Zebra Danio
Brachydanio rerio
NP_958476
896
98728
E271
S
R
P
V
H
H
K
E
I
L
K
L
I
K
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188203
734
80915
C138
S
P
K
P
S
Q
C
C
T
G
T
T
V
T
A
Poplar Tree
Populus trichocarpa
XP_002321013
915
101109
V282
M
P
K
V
S
K
L
V
N
E
L
Y
K
G
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
87.4
86.2
83.6
N.A.
22.3
73.7
N.A.
35.9
58.3
50.7
46.1
N.A.
N.A.
N.A.
N.A.
28.3
Protein Similarity:
100
87.7
87.7
92.6
N.A.
41.6
86
N.A.
50.7
74.6
69
64.6
N.A.
N.A.
N.A.
N.A.
45.8
P-Site Identity:
100
100
13.3
93.3
N.A.
0
93.3
N.A.
20
26.6
20
26.6
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
100
20
100
N.A.
20
100
N.A.
53.3
53.3
53.3
53.3
N.A.
N.A.
N.A.
N.A.
6.6
Percent
Protein Identity:
23.7
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
45.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
20
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
17
% A
% Cys:
9
9
0
0
0
0
9
9
0
0
0
34
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
9
% D
% Glu:
0
9
25
9
0
0
0
9
0
9
0
0
0
0
34
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% F
% Gly:
0
0
0
0
9
0
0
0
0
17
9
0
0
9
9
% G
% His:
9
0
0
0
9
42
17
9
0
0
0
9
0
0
0
% H
% Ile:
0
0
0
42
0
0
9
0
17
0
0
0
17
0
0
% I
% Lys:
0
50
17
0
0
17
9
0
0
0
50
0
17
59
9
% K
% Leu:
34
0
34
0
9
17
9
0
9
50
17
17
42
0
0
% L
% Met:
17
0
9
0
0
0
0
0
0
0
0
9
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
42
0
0
0
9
0
0
% N
% Pro:
0
17
17
9
0
0
0
0
0
0
0
0
0
9
0
% P
% Gln:
9
0
0
0
0
25
0
0
0
9
0
0
9
0
17
% Q
% Arg:
0
17
0
0
50
0
9
0
0
0
9
0
0
9
0
% R
% Ser:
25
0
0
0
25
0
9
0
17
9
9
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
9
17
0
9
9
0
17
0
% T
% Val:
0
0
0
34
0
0
0
9
0
9
0
9
9
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
0
34
50
0
0
0
9
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _